Deerfield Management Companies

Research Associate/ Senior Research Associate, Protein Purification

Job Locations US-CA-San Diego
Job Post Information* : Posted Date 1 month ago(12/10/2021 3:50 PM)
# of Openings
Research & Development


Research Associate / Sr. Research Associate, Protein Purification


AlivaMab Discovery Services is seeking an outstanding individual with a wide range of skills in antibody purification, analytics and recombinant protein expression to join our collaborative and innovative therapeutic antibody discovery team. Additional knowledge in antibody engineering and display systems is a plus. Title will be commensurate with experience.


AlivaMab Discovery Services is a rapidly growing leader in the discovery of human antibody therapeutics, trusted by top-tier pharmaceutical and biotechnology companies to deliver panels of drug-quality human antibodies. We deliver on our partners' design goals, from simple to extraordinarily challenging, through collaborative access to our scientists' creativity and experience combined with proven technologies, including the AlivaMab® Mouse suite of transgenic mice. We excel in the rapid and efficient delivery of molecularly diverse therapeutic antibody candidates, well-characterized for function, kinetics and developability, with expanding capabilities for engineering for alternative formats, including multispecifics and CARs. Our organization is dedicated to creating a healthier world through partnerships that bring better medicines to patients faster, and we recognize our success starts with hiring people who share our passion for science.



  • Conduct antibody purification and analytics (antibody purification based on protein A and ion exchange and antibody characterization via SDS-PAGE and SEC-HPLC).
  • Transient expression of antibodies using CHO-based expression systems.
  • Assist with molecular biology workflows.
  • Execute projects and prepare written reports.
  • Experimental design, experiment execution and troubleshooting.
  • Work closely with other team members and leaders.
  • Effectively present and communicate concepts and results, both orally and in writing, to colleagues and management.



Key Skills and Requirements:

  • BS/MS with a minimum of 3-5 years of related experience.
  • Strong knowledge of and skills in protein purification and analytics, specifically antibodies and various antibody formats.
  • Extensive experience using Protein A and ion exchange methods for antibody purification.
  • Experience with purification instrumentation such as Akta or similar.
  • Experience with SDS-PAGE and SEC-HPLC for antibody analysis.
  • Experience with molecular biology techniques (PCR, DNA/RNA isolation, plasmid prep, gel extraction, cloning, Sanger sequence analysis).
  • Ability to multitask.
  • Excellent trouble shooting and problem-solving capabilities.
  • Extraordinary attention to detail, planning skills and organizational skills.
  • History of timeline-driven delivery.
  • Outstanding oral and written communication skills.
  • Independent and creative researcher who demonstrate initiative.
  • Proficiency with Microsoft Office and instrument-specific software (Agilent Open Lab, GE Unicorn).
  • Experience with any of the following is a plus: antibody engineering and reformatting, high-throughput recombinant expression, NGS, therapeutic antibody developability assessments, performing and optimizing transient transfections of antibodies utilizing CHO-based suspension systems.

About AlivaMab Discovery Services

AlivaMab Discovery Services (ADS) sets its partners’ antibody discovery programs on the fastest and most de-risked path through discovery and development. Trusted by top-tier pharmaceutical and biotechnology companies, ADS delivers drug-quality, fully human antibodies on exceptional timelines. ADS achieves its partners’ design goals, from simple to extraordinarily challenging, through the generation and function-first screening of large, molecularly diverse panels of antibodies. ADS focuses on rapid and efficient delivery of antibodies, characterized for function, kinetics and developability, and engineering for alternative formats, including multispecifics and CARs. The ADS team’s experience and passion for antibody drug discovery and development combined with the use of trusted, proven technologies, including Ablexis' AlivaMab® Mouse platforms, ensure the highest probability of success.


AlivaMab Discovery Services provides equal employment opportunities (EEO) to all employees and applicants for employment without regard to religion, race, creed, color, sex, sexual orientation, gender identification, alienage or citizenship status, national origin, age, marital status, pregnancy, disability, veteran or military status, predisposing genetic characteristics or any other characteristic protected by applicable federal, state or local law.





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