Deerfield Management Companies

Senior Research Associate, Molecular Biology (Multiple Openings)

Job Locations US-CA-San Diego
Job Post Information* : Posted Date 1 week ago(5/16/2022 5:17 PM)
ID
2022-1721
# of Openings
2
Category
Research & Development

Overview

Senior Research Associate, Molecular Biology

Overview

AlivaMab Discovery Services is seeking an outstanding individual with exceptional molecular biology skills for the position of Senior Research Associate in the Molecular Biology and Protein Science group. The successful applicant will be responsible for planning and performing molecular biology activities in the Molecular Biology and Protein Science group. This position offers the opportunity for substantial career growth and the ability to help discover the medicines of tomorrow. The Senior Research Associate will work within the Molecular Biology team in the Antibody Engineering and Protein Science group and work closely with scientists and leaders in the Antibody Discovery group.

 

AlivaMab Discovery Services is a rapidly growing leader in the discovery of human antibody therapeutics, trusted by top-tier pharmaceutical and biotechnology companies to deliver panels of drug-quality human antibodies. We deliver on our partners' design goals, from simple to extraordinarily challenging, through collaborative access to our scientists' creativity and experience combined with proven technologies, including the AlivaMab® Mouse suite of transgenic mice. We excel in the rapid and efficient delivery of molecularly diverse therapeutic antibody candidates, well-characterized for function, kinetics and developability, with expanding capabilities for engineering for advanced modalities, including multispecifics and CARs. Our organization is dedicated to creating a healthier world through partnerships that bring better medicines to patients faster, and we recognize our success starts with hiring people who share our passion for science.

Responsibilities

Responsibilities

  • Design and construct vectors for antibody/protein expression, including advanced modalities such as multispecifics
  • Design constructs to generate various target antigens by understanding key protein interactions and assessing the state of current research in the field. Generate expression constructs for in vivo immunization and reagent cell line generation, including lentiviral vectors
  • Independently plan and execute experiments, analyze results and present data at team meetings
  • Generate, organize and maintain meticulous records all conducted experiments

Qualifications

Qualifications

Key Skills and Requirements:

  • BS with a minimum of 5 years of related experience or MS with a minimum of 2 years of related experience
  • Experience with molecular biology techniques (PCR, DNA/RNA isolation, gel extraction, cloning, Sanger sequence analysis, Gibson Assembly)
  • NGS experience, including adapter ligation, library validation and NGS data analysis
  • Antibody engineering, expression and purification is a plus
  • Experience with homology-based cloning methods (e.g., infusion and Gibson Assembly) desired
  • Experience with NGS sample prep and library generation/QC desired
  • Excellent troubleshooting and problem-solving capabilities
  • Extraordinary attention to detail, planning skills and organizational skills
  • Ability to manage multiple projects simultaneously
  • History of timeline-driven delivery
  • Outstanding presentation and communication skills. Ability to present in front of internal and external audiences
  • Thrives in a high-energy, goal- and timeline-driven environment
  • Good internal and external collaborative abilities, including excellent listening and creative problem solving
  • High functioning in an environment dedicated to exceptional quality and integrity
  • Proficiency in Microsoft Office, SnapGene and other programs necessary for the position

About AlivaMab Discovery Services

AlivaMab Discovery Services (ADS) sets its partners’ antibody discovery programs on the fastest and most de-risked path through discovery and development. Trusted by top-tier pharmaceutical and biotechnology companies, ADS delivers drug-quality, fully human antibodies on exceptional timelines. ADS achieves its partners’ design goals, from simple to extraordinarily challenging, through the generation and function-first screening of large, molecularly diverse panels of antibodies. ADS focuses on rapid and efficient delivery of antibodies, characterized for function, kinetics and developability, and engineering for advanced modalities, including multispecifics and CARs. The ADS team’s experience in antibody drug discovery and development comes from many of the world’s top 15 pharmaceutical companies, including AbbVie, AstraZeneca, Bristol Myers Squibb, Novartis, Pfizer and Roche/Genentech, and translates across more than 500 discovery programs and 35 clinical candidates. This experience, combined with the use of trusted, proven technologies, including Ablexis’ AlivaMab® Mouse platforms, ensures the highest probability of success.

AlivaMab Discovery Services provides equal employment opportunities (EEO) to all employees and applicants for employment without regard to religion, race, creed, color, sex, sexual orientation, gender identification, alienage or citizenship status, national origin, age, marital status, pregnancy, disability, veteran or military status, predisposing genetic characteristics or any other characteristic protected by applicable federal, state or local law.

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