Deerfield Management Companies

Research Associate II, Protein Purification

Job Locations US-CA-San Diego
Job Post Information* : Posted Date 2 weeks ago(1/25/2023 4:15 PM)
ID
2023-1857
# of Openings
1
Category
Research & Development

Overview

AlivaMab Discovery Services is seeking an outstanding individual with a wide range of skills in antibody purification, analytics and recombinant protein expression to join our collaborative and innovative therapeutic antibody discovery team. Additional knowledge in antibody engineering and display systems is a plus. Level (RA II +) will be commensurate with experience.

 

AlivaMab Discovery Services is a rapidly growing leader in the discovery of human antibody therapeutics, trusted by top-tier pharmaceutical and biotechnology companies to deliver panels of drug-quality human antibodies. We deliver on our partners' design goals, from simple to extraordinarily challenging, through collaborative access to our scientists' creativity and experience combined with proven technologies, including the AlivaMab® Mouse suite of transgenic mice. We excel in the rapid and efficient delivery of molecularly diverse therapeutic antibody candidates, well-characterized for function, kinetics and developability, with expanding capabilities for engineering for alternative formats, including multispecifics and CARs. Our organization is dedicated to creating a healthier world through partnerships that bring better medicines to patients faster, and we recognize our success starts with hiring people who share our passion for science.

Responsibilities

Responsibilities

 

  • Conduct antibody purification and analytics (antibody purification based on protein A and ion exchange and antibody characterization via SDS-PAGE and SEC-HPLC).
  • Transient expression of antibodies using CHO-based expression systems.
  • Assist with molecular biology workflows.
  • Execute projects and prepare written reports.
  • Experimental design, experiment execution and troubleshooting.
  • Work closely with other team members and leaders.
  • Effectively present and communicate concepts and results, both orally and in writing, to colleagues and management.

Qualifications

Key Skills and Requirements:

  • BS/MS with a minimum of 2 + years of related experience.
  • Strong knowledge of and skills in protein purification and analytics, specifically antibodies and various antibody formats.
  • Extensive experience using Protein A and ion exchange methods for antibody purification.
  • Experience with purification instrumentation such as Akta or similar.
  • Experience with SDS-PAGE and SEC-HPLC for antibody analysis.
  • Ability to multitask.
  • Excellent trouble shooting and problem-solving capabilities.
  • Extraordinary attention to detail, planning skills and organizational skills.
  • History of timeline-driven delivery.
  • Outstanding oral and written communication skills.
  • Independent and creative researcher who demonstrates initiative.
  • Proficiency with Microsoft Office and instrument-specific software (Agilent Open Lab, GE Unicorn).
  • Experience with any of the following is a plus: antibody engineering and reformatting, high-throughput recombinant expression, NGS, therapeutic antibody developability assessments, performing and optimizing transient transfections of antibodies utilizing CHO-based suspension systems.

About AlivaMab Discovery Services

 

AlivaMab Discovery Services (ADS) sets its partners’ antibody discovery programs on the fastest and most de-risked path through discovery and development. Trusted by top-tier pharmaceutical and biotechnology companies, ADS delivers drug-quality, fully human antibodies on exceptional timelines. ADS rapidly and efficiently delivers truly molecularly diverse panels of antibodies, characterized for function, kinetics, and developability, and offers downstream capabilities in antibody engineering for advanced modalities, including multispecifics and CARs. The ADS team’s experience in antibody drug discovery and development comes from many of the world’s top 15 pharmaceutical companies, including AbbVie, AstraZeneca, Bristol Myers Squibb, Novartis, Pfizer, and Roche/Genentech, and translates across more than 500 discovery programs and 35 clinical candidates. This experience, combined with the use of trusted, proven technologies, including Ablexis’ AlivaMab® Mouse platforms, ensures the highest probability of success.

 

AlivaMab Discovery Services provides equal employment opportunities (EEO) to all employees and applicants for employment without regard to religion, race, creed, color, sex, sexual orientation, alienage or citizenship status, national origin, age, marital status, pregnancy, disability, veteran or military status, predisposing genetic characteristics or any other characteristic protected by applicable federal, state or local law.

 

The annualized anticipated base salary for this Research Associate II position ranges from $67,000 to $82,000 Additionally, this position offers an annual bonus, equity, and other benefits. Compensation will be commensurate with experience and credentials.

 

Other benefits offered include a 401K retirement savings plan, paid time off (vacation/personal days, holidays, and sick time), long- and short-term disability, health benefits (medical, prescription drug, dental and vision insurance), gym access, and more.

 

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