Associate Scientist or Scientist, Protein Purification and Characterization

AlivaMab Discovery Services is seeking an outstanding individual with a wide range of skills in antibody purification, characterization and developability assessment to join our collaborative and innovative Antibody Engineering and Protein Sciences team. Additional knowledge in molecular biology and protein expression is a plus. Title will be commensurate with experience.

The annualized anticipated base annual salary for this Associate Scientist or Scientist position ranges from $90,000 to $127,000. Additionally, this position offers an annual bonus, equity, and other benefits.

Please note that individual total compensation for this position will be determined at the Company’s sole discretion and may vary based on several factors, including but not limited to: location, skill level, years and depth of relevant experience, and education.

Other benefits offered include a 401K retirement savings plan, paid time off (vacation/personal days, holidays, and sick time), long- and short-term disability, health benefits (medical, prescription drug, dental and vision insurance), gym access, and more.

AlivaMab Discovery Services is a rapidly growing leader in the discovery of human antibody therapeutics, trusted by top-tier pharmaceutical and biotechnology companies to deliver panels of drug-quality human antibodies. We deliver on our partners' design goals, from simple to extraordinarily challenging, through collaborative access to our scientists' creativity and experience combined with proven technologies, including the AlivaMab® Mouse suite of transgenic mice. We excel in the rapid and efficient delivery of molecularly diverse therapeutic antibody candidates, well-characterized for function, kinetics and developability, with expanded capabilities for engineering of alternative formats, including multispecifics and CARs. Our organization is dedicated to creating a healthier world through partnerships that bring better medicines to patients faster, and we recognize our success starts with hiring people who share our passion for science.

• Design and conduct small to mid-scale antibody purification by affinity, ion-exchange and other chromatographic methods from hybridoma and recombinant expression
• Perform protein characterization for quality control and developability assessment to assess stability, purity, polyspecificity and other biophysical properties
• Develop purifications methods for difficult-to-handle antibodies and optimize platform processes for higher production yields and product stability
• Support developing automated high throughput purification workflows
• Assist with molecular biology workflows and transient expression of antibodies using mammalian expression systems, as needed
• Execute projects and prepare written reports
• Experimental design, experiment execution and troubleshooting
• Work closely with other team members and leaders.
• Effectively present and communicate concepts and results, both orally and in writing, to colleagues and management.

Key Skills and Requirements:

• Bachelors in Biology, Chemistry, Biochemistry, or other disciplines required (Masters & beyond, preferred) with a minimum of 3+ years of related experience in industry
• Strong knowledge of and skills in purification and analytics, specifically antibodies and various antibody formats
• Extensive experience using Protein A and ion exchange methods for antibody purification.
• Experience with purification instrumentation such as AKTA or similar
• Experience with SDS-PAGE, SEC-HPLC, SEC-MALS and mass spectrometry-based methods for antibody analysis. Familiarity with hydrophobic ion exchange chromatography and polyspecificity characterization
• Experience with molecular biology techniques (PCR, DNA/RNA isolation, plasmid prep, gel extraction, cloning, Sanger sequence analysis)
• Ability to multitask
• Excellent trouble shooting and problem-solving capabilities
• Extraordinary attention to detail, planning skills and organizational skills
• History of timeline-driven delivery
• Outstanding oral and written communication skills
• Independent and creative researcher who demonstrates initiative
• Proficiency with Microsoft Office and instrument-specific software (Agilent Open Lab, GE Unicorn)
• Experience with any of the following is a plus: Chemical conjugation, high-throughput recombinant expression, therapeutic antibody developability assessments, performing and optimizing transient transfections of antibodies utilizing CHO-based suspension systems

About AlivaMab Discovery Services

AlivaMab Discovery Services (ADS) sets its partners’ antibody discovery programs on the fastest and most de-risked path through discovery and development. Trusted by top-tier pharmaceutical and biotechnology companies, ADS delivers drug-quality, fully human antibodies on exceptional timelines. ADS achieves its partners’ design goals for antibody drug discovery and engineering, from simple to extraordinarily challenging, rapidly and efficiently through the generation and fit-for-purpose screening of large, molecularly diverse panels of antibodies, characterized for function, kinetics and developability, and engineering for alternative formats, including multispecifics and CARs. The ADS team’s experience and passion for antibody drug discovery and development combined with the use of trusted, proven technologies, including Ablexis' AlivaMab® Mouse platforms, ensure the highest probability of success.

AlivaMab Discovery Services provides equal employment opportunities (EEO) to all employees and applicants for employment without regard to religion, race, creed, color, sex, sexual orientation, gender identification, alienage or citizenship status, national origin, age, marital status, pregnancy, disability, veteran or military status, predisposing genetic characteristics or any other characteristic protected by applicable federal, state or local law.

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