Deerfield Management Companies

Senior Scientist, Antibody Engineering

Job Locations US-CA-San Diego
Job Post Information* : Posted Date 2 months ago(5/1/2024 3:45 PM)
ID
2024-1995
# of Openings
1
Category
Research & Development

Overview

Senior Scientist, Antibody Engineering

Overview

AlivaMab Biologics is seeking an outstanding Senior Scientist, Antibody Engineering to lead our antibody engineering and molecular biology teams. This position will lead a team of research associates responsible for conducting phage display-based antibody discovery and the designing, generating, and characterizing of antibody-based therapeutics, including advanced modalities such as multispecifics and single-domain antibodies. The successful candidate will report to the Sr. Director of Antibody Engineering and Protein Sciences and work closely with scientists and leaders in the Antibody Discovery, Protein Sciences, and Project Management Group. The position requires a large body of work at the lab bench. This role provides a unique opportunity to contribute to the expansion of antibody discovery and engineering capabilities at AlivaMab Biologics.

 

AlivaMab Biologics is a rapidly growing leader in the discovery of human antibody therapeutics, trusted by top-tier pharmaceutical and biotechnology companies to deliver panels of drug-quality human antibodies. We deliver on our partners' design goals, from simple to extraordinarily challenging, through collaborative access to our scientists' creativity and experience combined with proven technologies, including the AlivaMab® Mouse suite of transgenic mice. We excel in the rapid and efficient delivery of molecularly diverse therapeutic antibody candidates, well-characterized for function, kinetics, and developability, with expanding capabilities for engineering advanced modalities, including multispecifics, single-domain human VH antibodies, and CARs. Our organization is dedicated to creating a healthier world through partnerships that bring better medicines to patients faster, and we recognize our success starts with hiring people who share our passion for science.

Responsibilities

 

  • Develop and execute a robust phage-based immune repertoire display platform for forced common light chain and single domain human VH antibody discovery and optimization.
  • Lead an antibody engineering and molecular biology team responsible for designing, generating, and characterizing antibody-based therapeutics, including advanced modalities such as multispecific antibodies and single-domain human VH antibodies.
  • Design, lead, and execute engineering campaigns to deliver cutting-edge, developable biologics formats by applying phage display, molecular biology, structure-guided, and computational approaches.
  • Lead technology development in antibody engineering and molecular biology.
  • Develop and employ complex molecular biology workflows to rapidly generate constructs from various sources.
  • Interact and collaborate with leaders and teams across antibody discovery, protein sciences, and project management on project delivery and new technology development.
  • Create precise technical summaries and protocols, and maintain proper documentation and data reporting in ELN.
  • This is a full-time and lab-based position.

Qualifications

 

Key Skills and Requirements:

  • PhD in a relevant scientific area, such as antibody or protein engineering, protein biochemistry, or biotechnology, plus at least five years of professional experience in biologics research.
  • Hands-on experience with antibody phage display platforms is required.
  • Deep understanding of diverse biologics formats, including bi- and multispecific antibodies, and single-domain antibodies is required.
  • Background in structure-based antibody design and engineering is desired.
  • Experience with antibody engineering is preferred.
  • Excellent communicator and highly effective in interacting with key internal and external stakeholders.
  • Team player and builder, possess great coaching skills, and have great organizational skills.
  • High degree of integrity and professionalism and dedication to exceptional quality and integrity.

 

About AlivaMab Biologics

AlivaMab Biologics sets its partners’ antibody discovery programs on the fastest and most de-risked path through discovery and development. Trusted by top-tier pharmaceutical and biotechnology companies, AMB delivers drug-quality, fully human antibodies on exceptional timelines. AMB achieves its partners’ design goals, from simple to extraordinarily challenging, through the generation and function-first screening of large, molecularly diverse panels of antibodies. AMB focuses on rapid and efficient delivery of antibodies, characterized for function, kinetics and developability, and engineering for alternative formats, including multi-specifics and CARs. The AMB team’s experience and passion for antibody drug discovery and development combined with the use of trusted, proven technologies, including Ablexis' AlivaMab® Mouse platforms, ensure the highest probability of success.

AlivaMab Biologics provides equal employment opportunities (EEO) to all employees and applicants for employment without regard to religion, race, creed, color, sex, sexual orientation, gender identification, alienage or citizenship status, national origin, age, marital status, pregnancy, disability, veteran or military status, predisposing genetic characteristics or any other characteristic protected by applicable federal, state or local law.

 

The compensation range for this position is $136,000 - $171,000.

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